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Freeze-drying process control _ vacuum pump system

by:J&T     2020-06-29

freeze-drying process, vacuum control precision whether smooth, is one of the important indexes of the lyophilizer hardware capability.

at the same time, because of a dry vacuum, directly affect product sublimation interface temperature. So smooth precise control of vacuum degree, is vital for a drying process.

the pressure inside the lyophilizer control, can be done by two ways, gas permeability ( Upstream vacuum water pump control system) And downstream vacuum pump control system.

this article will explain in detail the mechanical principle and advantages and disadvantages of two kinds of vacuum pump system.

1。 Downstream of the vacuum pump system control

by vacuum pump and cold well between the valve and to control the vacuum degree.

by installing electromagnetic valve between the vacuum pump and cold well, to control the vacuum degree. Through the valve open and close to control the vacuum degree in the body cavity. Control of vacuum degree not as accurate as upstream vacuum degree.

advantage: not enter additional gas.

faults: coarse vacuum pump system control, unable to control the vacuum change slope.

2。 Upstream vacuum pump system control

by adjusting the headwaters of the sample chamber permeability gas to control the opening and closing of the valve Angle vacuum system. By this way can realize accurate vacuum pump control system; Can choose the gas into the air or some other type. Sterile air:

advantage: the air inlet is not positive pressure.

disadvantages: the risk of oxygen. High pressure cases ( 0. 700mbar) The oxidation products; There might be water vapor in the air. Sterile nitrogen

:

advantage: the sterile and dry.

weakness: the inlet pressure must be controlled.

by adjusting the headwaters of the sample chamber permeability gas to control the opening and closing of the valve Angle vacuum system. By this way can realize precise vacuum water pump control system.

upstream vacuum pump system control:

more accurate adjustment.

the slope can be set pressure change.

sustainable sublimation gas inlet into cold trap.

process are of great help for bulk samples.


winter cover pump water pump processes have been widely used to produce pool cover drain pump such as winter cover pump, pool cover drain pump, and winter cover pump etc.
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